Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 15/20 | 0.48 |
| ▸ | FNTB | P49356 | 15/20 | 0.48 |
| ▸ | PGGT1B | P53609 | 15/20 | 0.48 |
| ▸ | HRH1 | P35367 | 4/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 3/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7168713 | 0.87 | FNTA (0.45) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL6409301 | 0.81 | HRH1 (0.44) | HRH1HTR1ADRD4HTR2AOPRM1 | |
| SCHEMBL7163804 | 0.78 | CYP11B1 (0.46) | FNTAFNTBPGGT1BSLC6A3CYP11B1 | |
| SCHEMBL7189205 | 0.78 | KCNH2 (0.44) | FNTAFNTBPGGT1BSIGMAR1CYP11B1 | |
| SCHEMBL7165997 | 0.76 | FNTA (0.43) | FNTAFNTBPGGT1BDRD4HTR2A | |
| SCHEMBL7164885 | 0.76 | HTR2A (0.38) | FNTAFNTBPGGT1BDRD4HTR2A | |
| SCHEMBL7713236 | 0.74 | CYP11B1 (0.70) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7163166 | 0.74 | CYP11B1 (0.55) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7971164 | 0.74 | CYP11B1 (0.52) | CYP11B1CYP11B2 | |
| Bromide SCHEMBL6409239 | 0.73 | CYP11B1 (0.54) | FNTAFNTBPGGT1BCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |