Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 5/20 | 0.38 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6409500 | 0.99 | CCR5 (0.38) | CCR5CCR2PDE4BALDH1A1SMN1; SMN2 | |
| SCHEMBL6412947 | 0.94 | CCR5 (0.39) | CCR5CCR2PDE4BALDH1A1KCNH2 | |
| Hydrochloric Acid SCHEMBL6412939 | 0.93 | CCR5 (0.39) | CCR5CCR2PDE4BALDH1A1KCNH2 | |
| SCHEMBL6414389 | 0.93 | CCR5 (0.37) | CCR5CCR2PDE4BALDH1A1SMN1; SMN2 | |
| SCHEMBL6408943 | 0.90 | CCR5 (0.47) | CCR5CCR2SMN1; SMN2KCNH2MMP1 | |
| SCHEMBL6416700 | 0.90 | HPGD (0.38) | CCR5PDE4BALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL6411170 | 0.90 | CCR5 (0.44) | CCR5CCR2MMP1MMP9MMP13 | |
| Hydrochloric Acid SCHEMBL6408939 | 0.89 | CCR5 (0.46) | CCR5CCR2KCNH2MMP1MMP9 | |
| Hydrochloric Acid SCHEMBL6416695 | 0.89 | HPGD (0.38) | CCR5PDE4BALDH1A1SMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL5256271 | 0.89 | CCR5 (0.43) | CCR5CCR2MMP1MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | CCR5 4/4885CCR2 5/4885PDE4B 1290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.