Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 2/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | CLPP | Q16740 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | GNRHR | P30968 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6417635 | 1.00 | HCRTR2 (0.48) | HCRTR2OPRM1OPRD1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL6408290 | 0.99 | HCRTR2 (0.48) | HCRTR2OPRM1OPRD1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL5252414 | 0.99 | HCRTR2 (0.48) | HCRTR2OPRM1OPRD1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL6409388 | 0.99 | HCRTR2 (0.48) | HCRTR2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL6410623 | 0.91 | HCRTR2 (0.51) | HCRTR2OPRM1OPRD1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL6412444 | 0.91 | HCRTR2 (0.44) | HCRTR2OPRM1OPRD1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL6414690 | 0.90 | HCRTR2 (0.50) | HCRTR2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL6409014 | 0.90 | CCR3 (0.46) | HCRTR2OPRM1OPRL1CCR3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5304374 | 0.88 | CCR3 (0.45) | HCRTR2OPRM1OPRL1CCR3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6409157 | 0.88 | HCRTR2 (0.42) | HCRTR2CLPPALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | HCRTR2 247/4885OPRM1 244/4885OPRD1 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.