Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5304374 | 0.99 | CCR3 (0.45) | CCR3MEN1KMT2ARIPK1HCRTR1 | |
| Hydrochloric Acid SCHEMBL6430719 | 0.92 | OPRM1 (0.45) | CCR3MEN1KMT2ASIGMAR1TACR1 | |
| Hydrochloric Acid SCHEMBL6417628 | 0.92 | OPRM1 (0.45) | CCR3MEN1KMT2ASIGMAR1TACR1 | |
| SCHEMBL6411982 | 0.92 | HSD11B1 (0.43) | CCR3MEN1KMT2ARIPK1HCRTR1 | |
| Hydrochloric Acid SCHEMBL6409417 | 0.91 | HSD11B1 (0.42) | CCR3MEN1KMT2ARIPK1HCRTR1 | |
| Hydrochloric Acid SCHEMBL6416497 | 0.91 | HSD11B1 (0.42) | CCR3MEN1KMT2ARIPK1HCRTR1 | |
| Hydrochloric Acid SCHEMBL6409309 | 0.91 | CCR2 (0.50) | CCR3MEN1KMT2ARIPK1HCRTR1 | |
| Hydrochloric Acid SCHEMBL6409945 | 0.91 | CCR3 (0.51) | CCR3MEN1KMT2ARIPK1SIGMAR1 | |
| SCHEMBL6409581 | 0.90 | HCRTR2 (0.48) | CCR3MEN1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL6417635 | 0.90 | HCRTR2 (0.48) | CCR3MEN1KMT2AHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | claimed |
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | CCR3 13/4885MEN1 4007/4885KMT2A 4587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.