Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4961899 | 0.90 | HSD11B1 (0.64) | HSD11B1MAPK1ALDH1A1 | |
| SCHEMBL5950324 | 0.90 | HSD11B1 (0.64) | HSD11B1MAPK1ALDH1A1 | |
| SCHEMBL5950753 | 0.89 | HSD11B1 (0.62) | HSD11B1ALDH1A1 | |
| SCHEMBL4002241 | 0.86 | HSD11B1 (0.63) | HSD11B1TSHRMAPK1LMNAMMP2 | |
| SCHEMBL4002244 | 0.86 | HSD11B1 (0.63) | HSD11B1TSHRMAPK1LMNAMMP2 | |
| SCHEMBL5950699 | 0.82 | HSD11B1 (0.68) | HSD11B1 | |
| SCHEMBL4010554 | 0.81 | HSD11B1 (0.75) | HSD11B1TSHRMAPK1LMNAALDH1A1 | |
| SCHEMBL612467 | 0.81 | HSD11B1 (0.75) | HSD11B1TSHRMAPK1LMNAALDH1A1 | |
| SCHEMBL4006904 | 0.81 | HSD11B1 (0.61) | HSD11B1TSHRMAPK1LMNAMMP2 | |
| SCHEMBL4006910 | 0.81 | HSD11B1 (0.61) | HSD11B1TSHRMAPK1LMNAMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288338-A1 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2005-12-29 | — | — | US | claimed |
| US-20050288338-A1 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288338-A1 | Amido compounds and their use as pharmaceuticals | HSD11B1, CYP11B1, HSD11B2 | HSD11B1 1/4885TSHR 298/4885MAPK1 829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.