Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2400767 | 0.82 | TSHR (0.44) | TSHRGAACYP2C19KMT2AALDH1A1 | |
| SCHEMBL6409697 | 0.80 | TSHR (0.48) | TSHRGAACYP2C19KMT2AALDH1A1 | |
| SCHEMBL2403146 | 0.79 | CYP2C19 (0.43) | TSHRGAACYP2C19KMT2AALDH1A1 | |
| SCHEMBL2399883 | 0.76 | MAPT (0.48) | TSHRGAACYP2C19KMT2ANPSR1 | |
| SCHEMBL2400740 | 0.75 | MAPT (0.41) | TSHRGAACYP2C19KMT2AALDH1A1 | |
| SCHEMBL2401882 | 0.75 | GAA (0.42) | TSHRGAACYP2C19KMT2AALDH1A1 | |
| SCHEMBL6409700 | 0.74 | TSHR (0.47) | TSHRGAACYP2C19KMT2AALDH1A1 | |
| SCHEMBL2401310 | 0.74 | MAPK1 (0.46) | KMT2AALDH1A1RAB9ALMNA | |
| SCHEMBL2401835 | 0.74 | MERTK (0.42) | ALDH1A1NPSR1HPGDMAPTHSD17B10 | |
| SCHEMBL2400743 | 0.72 | ALDH1A1 (0.49) | GAACYP2C19KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | claimed |