Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 9/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7164885 | 0.83 | HTR2A (0.38) | HTR2AHTR2CSLC6A4DRD4SLC6A2 | |
| SCHEMBL6417857 | 0.75 | HTR2A (0.42) | HTR2AHTR2CSLC6A4DRD4SLC6A2 | |
| SCHEMBL6409301 | 0.75 | HRH1 (0.44) | HTR2AHTR2CDRD4HTR7SIGMAR1 | |
| SCHEMBL7163807 | 0.74 | KCNH2 (0.44) | SLC6A4SLC6A2SIGMAR1KCNH2KCNJ1 | |
| SCHEMBL8163840 | 0.73 | KCNH2 (0.45) | SIGMAR1KCNH2KCNJ1GPR52ACHE | |
| SCHEMBL6433917 | 0.67 | DAO (0.46) | GPR52 | |
| SCHEMBL6432281 | 0.67 | DAO (0.42) | GPR52 | |
| SCHEMBL7743907 | 0.66 | DAO (0.47) | GPR52 | |
| Bromide SCHEMBL6409244 | 0.66 | DAO (0.42) | GPR52 | |
| SCHEMBL2724944 | 0.66 | KCNH2 (0.59) | HTR2AHTR2CSLC6A4DRD4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |