Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7745910 | 0.99 | DAO (0.46) | DAOHRH1HTR1BTRPV4HRH4 | |
| Hydrochloric Acid SCHEMBL6438009 | 0.92 | DAO (0.45) | DAOHRH1HTR1BTRPV4GPR52 | |
| SCHEMBL6433917 | 0.88 | DAO (0.46) | DAOTRPV4GPR52CYP11B1CYP11B2 | |
| SCHEMBL6432281 | 0.82 | DAO (0.42) | DAOGPR52CYP11B1CYP11B2 | |
| SCHEMBL7843395 | 0.82 | HRH3 (0.47) | DAOHRH1HTR1BHRH4NSD2 | |
| Bromide SCHEMBL6409244 | 0.81 | DAO (0.42) | DAOGPR52CYP11B1CYP11B2 | |
| SCHEMBL7163807 | 0.80 | KCNH2 (0.44) | DAOHRH1GPR52NSD2 | |
| SCHEMBL8163840 | 0.79 | KCNH2 (0.45) | DAOGPR52NSD2 | |
| SCHEMBL7715298 | 0.79 | DAO (0.51) | DAOTRPV4CYP11B1CYP11B2 | |
| SCHEMBL6409770 | 0.79 | DAO (0.43) | DAOTRPV4GPR52CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091736-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1091736-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-2001017992-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |
| WO-2000001382-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |