Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.40 |
| ▸ | CCND1 | P24385 | 5/20 | 0.40 |
| ▸ | CDK2 | P24941 | 5/20 | 0.40 |
| ▸ | CDK1 | P06493 | 3/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.39 |
| ▸ | CDK11A | Q9UQ88 | 3/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 2/20 | 0.34 |
| ▸ | CDK14 | O94921 | 2/20 | 0.34 |
| ▸ | CCNY | Q8ND76 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6407207 | 0.95 | CDK4 (0.42) | CDK4CCND1CDK2CDK1CCNT1 | |
| Trifluoroacetic Acid SCHEMBL6197402 | 0.92 | CDK2 (0.41) | CDK4CCND1CDK2CDK1CCNT1 | |
| Hydrochloric Acid SCHEMBL6193856 | 0.90 | CDK4 (0.43) | CDK4CCND1CDK2CDK1CCNT1 | |
| Trifluoroacetic Acid SCHEMBL6197563 | 0.89 | CDK4 (0.41) | CDK4CCND1CDK2CDK1CCNT1 | |
| Trifluoroacetic Acid SCHEMBL6407484 | 0.88 | CDK2 (0.40) | CDK4CCND1CDK2CDK1CCNT1 | |
| Trifluoroacetic Acid SCHEMBL6197522 | 0.88 | CDK4 (0.40) | CDK4CCND1CDK2CDK1CCNT1 | |
| SCHEMBL6197278 | 0.88 | CDK2 (0.45) | CDK4CCND1CDK2CDK1CCNT1 | |
| Trifluoroacetic Acid SCHEMBL6200930 | 0.86 | CDK4 (0.41) | CDK4CCND1CDK2CDK1CCNT1 | |
| Hydrochloric Acid SCHEMBL6198647 | 0.86 | CDK4 (0.43) | CDK4CCND1CDK2CDK1CCNT1 | |
| Hydrochloric Acid SCHEMBL6198917 | 0.86 | CDK4 (0.43) | CDK4CCND1CDK2CDK1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050101595-A1 | N-containing cycloalkyl-substituted amino-thiazole derivatives and pharmaceutical compositions for inhibiting cell proliferation and methods for their use | PFIZER INC. | 2005-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101595-A1 | N-containing cycloalkyl-substituted amino-thiazole derivatives and pharmaceutical compositions for inhibiting cell proliferation and methods for their use | CCNI, MKI67, TK1 | CDK4 78/4885CCND1 61/4885CDK2 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.