⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12224296 | 1.00 | LIPA (0.32) | — | |
| SCHEMBL13640707 | 0.90 | LIPA (0.42) | — | |
| SCHEMBL23570077 | 0.87 | — | — | |
| SCHEMBL765362 | 0.86 | — | — | |
| SCHEMBL6114283 | 0.86 | — | — | |
| SCHEMBL2450112 | 0.85 | TSHR (0.33) | — | |
| SCHEMBL2449244 | 0.85 | TSHR (0.33) | — | |
| SCHEMBL2449842 | 0.85 | TSHR (0.33) | — | |
| SCHEMBL1034374 | 0.83 | PDK1 (0.34) | — | |
| SCHEMBL18068060 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303495-A9 | PYRIDINE OXYNITRIDE, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI JEYOU PHARMACEUTICAL CO., LTD. (CN) | 2023-09-28 | — | — | US | disclosed |
| EP-3694858-B1 | BICYCLIC COMPOUNDS FOR USE AS RIP1 KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2023-01-11 | — | — | EP | disclosed |
| EP-3759096-B1 | CD73 INHIBITORS | LILLY CO ELI (US) | 2022-02-16 | — | — | EP | disclosed |
| WO-2021252307-A1 | RIPK1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2021-12-16 | — | — | WO | disclosed |
| US-20210277003-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2021-09-09 | — | — | US | disclosed |
| WO-2021047622-A1 | PYRIDINE OXYNITRIDE, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海济煜医药科技有限公司 | 2021-03-18 | — | — | WO | disclosed |
| WO-2020249791-A1 | SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | disclosed |
| EP-3677579-A1 | HETEROCYCLIC GLS1 INHIBITORS | Board of Regents, The University of Texas System (US) | 2020-07-08 | — | — | EP | disclosed |
| EP-3164394-B1 | GLS1 INHIBITORS FOR TREATING DISEASES | UNIV TEXAS (US) | 2020-04-01 | — | — | EP | disclosed |
| WO-2019079632-A1 | GLUTAMINASE INHIBITOR THERAPY | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-04-25 | — | — | WO | disclosed |
| US-20080262036-A1 | Phenyl-[1,2,4]-oxadiazol-5-one Derivatives, Pharmaceutical Compositions and Therapeutic Use Thereof | SANOFI-AVENTIS (FR) | 2008-10-23 | — | — | US | disclosed |
| US-20050053552-A1 | Phase shift colloids as ultrasound contrast agents | QUAY STEVEN C (US) | 2005-03-10 | — | — | US | disclosed |
| US-6569404-B1 | Aqueous colloidal suspension, dispersed phase is gas microbubbles of perfluoropropane, perfluorobutane, perfluoropentane, perfluorohexane or sulfur hexafluoride; fluorinated amphiphile for stabilizing microbubbles | AMERSHAM HEALTH A/S (NO) | 2003-05-27 | — | — | US | disclosed |
| US-6245319-B1 | Colloidal dispersions of perfluoropentane | SONUS PHARMACEUTICALS, INC. | 2001-06-12 | — | — | US | disclosed |
| EP-0680341-B1 | PHASE SHIFT COLLOIDS AS ULTRASOUND CONTRAST AGENTS | SONUS PHARMA INC (US) | 2001-05-09 | — | — | EP | disclosed |
| EP-1038535-A2 | Use of selected perfluorocarbons for the preparation of diagnostic ultrasound contrast agents | SONUS PHARMACEUTICALS, INC. (US) | 2000-09-27 | — | — | EP | disclosed |
| US-5876696-A | Composition comprising a fluorine containing surfactant and perfluoropentane for ultrasound | SONUS PHARMACEUTICALS, INC. (US) | 1999-03-02 | — | — | US | disclosed |
| US-5558853-A | WATER IMMISCIBLE FLUORINE COMPOUND | SONUS PHARMACEUTICALS (US) | 1996-09-24 | — | — | US | disclosed |
| EP-0680341-A1 | PHASE SHIFT COLLOIDS AS ULTRASOUND CONTRAST AGENTS | SONUS PHARMACEUTICALS, INC. (US) | 1995-11-08 | — | — | EP | disclosed |
| WO-1994016739-A1 | PHASE SHIFT COLLOIDS AS ULTRASOUND CONTRAST AGENTS | SONUS PHARMACEUTICALS, INC. (US) | 1994-08-04 | — | — | WO | disclosed |