SCHEMBL6410568

SCHEMBL6410568

O=C(CBr)CC(=O)Nc1cccc(C(F)(F)F)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.65
MEN1 O00255 5/20 0.65
KMT2A Q03164 5/20 0.65
GAA P10253 1/20 0.65
XBP1 P17861 1/20 0.65
NPSR1 Q6W5P4 1/20 0.65
ALDH1A1 P00352 5/20 0.64
SMN1; SMN2 Q16637 1/20 0.62
HDAC3 O15379 1/20 0.59
HDAC1 Q13547 1/20 0.59
HDAC2 Q92769 1/20 0.59
HDAC10 Q969S8 1/20 0.59
HDAC11 Q96DB2 1/20 0.59
HDAC8 Q9BY41 1/20 0.59
HDAC6 Q9UBN7 1/20 0.59
NCOR2 Q9Y618 1/20 0.59
L3MBTL1 Q9Y468 2/20 0.58
HTT P42858 2/20 0.57
RAB9A P51151 1/20 0.57
RECQL P46063 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29485038 0.89 MAPT (0.70) MAPTMEN1KMT2AGAAXBP1
SCHEMBL240730 0.89 MAPT (0.70) MAPTMEN1KMT2AGAAXBP1
SCHEMBL31236338 0.88 MAPT (0.77) MAPTMEN1KMT2AGAAXBP1
SCHEMBL5142590 0.88 MAPT (0.77) MAPTMEN1KMT2AGAAXBP1
SCHEMBL3045461 0.85 MAPT (0.65) MAPTMEN1KMT2AGAAXBP1
SCHEMBL433736 0.85 MEN1 (0.71) MAPTMEN1KMT2AGAAXBP1
SCHEMBL29410736 0.83 MAPT (0.70) MAPTMEN1KMT2AGAAXBP1
SCHEMBL3423702 0.83 MAPT (0.70) MAPTMEN1KMT2AGAAXBP1
SCHEMBL5142569 0.83 MAPT (0.77) MAPTMEN1KMT2AGAAXBP1
SCHEMBL11437364 0.82 HDAC3 (0.74) MAPTMEN1KMT2AGAAXBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6921770-B2 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2005-07-26 US disclosed
EP-1311160-A4 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INST SCI & TECH (KR) 2004-04-21 EP disclosed
US-20030203950-A1 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-10-30 US disclosed
EP-1311160-A1 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-05-21 EP disclosed
WO-2002013611-A1 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2002-02-21 WO disclosed
US-4152329-A 2-ACYLAMINOTHIAZOL-4-YLACETAMIDES AS POST-EMERGENT SELECTIVE HERBICIDES GULF OIL CORPORATION (US) 1979-05-01 US disclosed
US-4120690-A 2-Acylaminothiazol-4-ylacetamides as post-emergent selective herbicides GULF OIL CORPORATION (US) 1978-10-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030203950-A1 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same TYR, SYPL1, SSBP1 MAPT 1315/4885MEN1 131/4885KMT2A 2739/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.