Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 3/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | CA3 | P07451 | 3/20 | 0.49 |
| ▸ | CA4 | P22748 | 3/20 | 0.49 |
| ▸ | CA6 | P23280 | 3/20 | 0.49 |
| ▸ | CA5A | P35218 | 3/20 | 0.49 |
| ▸ | CA7 | P43166 | 3/20 | 0.49 |
| ▸ | CA9 | Q16790 | 3/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.49 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.49 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.49 |
| ▸ | DPP4 | P27487 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6411645 | 1.00 | SLC22A12 (0.49) | SLC22A12KDM4EHSD17B10ALDH1A1CA12 | |
| SCHEMBL922228 | 0.87 | KDM4E (0.49) | SLC22A12KDM4EHSD17B10ALDH1A1CA12 | |
| SCHEMBL19900021 | 0.87 | KDM4E (0.49) | SLC22A12KDM4EHSD17B10ALDH1A1CA12 | |
| SCHEMBL922227 | 0.87 | KDM4E (0.49) | SLC22A12KDM4EHSD17B10ALDH1A1CA12 | |
| SCHEMBL6370153 | 0.85 | SLC22A12 (0.44) | SLC22A12KDM4EHSD17B10ALDH1A1CA12 | |
| SCHEMBL8153860 | 0.85 | KDM4E (0.56) | SLC22A12KDM4EHSD17B10ALDH1A1CA12 | |
| SCHEMBL8153863 | 0.85 | KDM4E (0.56) | SLC22A12KDM4EHSD17B10ALDH1A1CA12 | |
| SCHEMBL26623542 | 0.84 | SLC22A12 (0.47) | SLC22A12KDM4EHSD17B10ALDH1A1CA12 | |
| SCHEMBL9839942 | 0.83 | TRPV4 (0.40) | SLC22A12HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9839936 | 0.83 | TRPV4 (0.40) | SLC22A12HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |