Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 18/20 | 0.57 |
| ▸ | NR1H3 | Q13133 | 13/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405303 | 0.86 | NR1H2 (0.65) | NR1H2NR1H3ALDH1A1GAA | |
| SCHEMBL6410481 | 0.86 | NR1H2 (0.60) | NR1H2NR1H3ALDH1A1GAATP53 | |
| SCHEMBL6100301 | 0.85 | NR1H2 (0.61) | NR1H2NR1H3ALDH1A1GAA | |
| SCHEMBL6405513 | 0.82 | NR1H2 (0.44) | NR1H2NR1H3 | |
| SCHEMBL6404754 | 0.81 | NR1H2 (0.48) | NR1H2NR1H3 | |
| SCHEMBL6408328 | 0.80 | NR1H2 (0.46) | NR1H2NR1H3 | |
| SCHEMBL6100597 | 0.80 | NR1H2 (0.69) | NR1H2NR1H3 | |
| SCHEMBL6098553 | 0.79 | NR1H2 (0.62) | NR1H2 | |
| SCHEMBL6406340 | 0.79 | NR1H2 (0.56) | NR1H2NR1H3 | |
| SCHEMBL6406547 | 0.79 | NR1H2 (0.59) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534696-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | Merck & Co., Inc. (US) | 2005-06-01 | — | — | EP | claimed |
| WO-2004011448-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | MERCK & CO., INC. (US) | 2004-02-05 | — | — | WO | claimed |