Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL639469 | 0.98 | EPHX1 (0.38) | CYP2D6CYP2C19EPHX1TBXAS1HRH4 | |
| SCHEMBL642265 | 0.95 | CYP2D6 (0.38) | CYP2D6CYP2C19EPHX1TBXAS1HRH4 | |
| SCHEMBL6516711 | 0.81 | ADRA1A (0.48) | CYP2D6CYP2C19ADRA1ATDP1 | |
| SCHEMBL6014602 | 0.79 | ADRA1A (0.52) | ADRA1ATDP1 | |
| SCHEMBL636777 | 0.79 | CYP2C19 (0.44) | CYP2C19TBXAS1PAOXTET2ADRA1A | |
| SCHEMBL432887 | 0.78 | TSHR (0.44) | EPHX1PAOXFNTAFNTBTDP1 | |
| SCHEMBL638323 | 0.78 | KDM4E (0.39) | CYP2D6CYP2C19TBXAS1TET2ADRA1A | |
| SCHEMBL1898746 | 0.78 | CYP2C19 (0.43) | CYP2C19TBXAS1PAOXADRA1AFNTA | |
| SCHEMBL18398909 | 0.78 | CYP2C19 (0.43) | CYP2C19TBXAS1PAOXADRA1AFNTA | |
| SCHEMBL635765 | 0.78 | PAOX (0.50) | TBXAS1PAOXFNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090103045-A1 | SILICONE HYDROGELS WITH AMINO SURFACE GROUPS | SALIX PHARMACEUTICALS, INC. | 2009-04-23 | — | — | US | claimed |
| US-8119753-B2 | Silicone hydrogels with amino surface groups | BAUSCH & LOMB INCORPORATED (US) | 2012-02-21 | — | — | US | disclosed |
| US-20090103045-A1 | SILICONE HYDROGELS WITH AMINO SURFACE GROUPS | SALIX PHARMACEUTICALS, INC. | 2009-04-23 | — | — | US | disclosed |