Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 11/20 | 0.72 |
| ▸ | HRH1 | P35367 | 11/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.72 |
| ▸ | HRH2 | P25021 | 1/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6413251 | 0.91 | CYP2D6 (0.74) | CYP2D6HRH1KCNH2HRH2CHRM1 | |
| SCHEMBL6277449 | 0.88 | CYP2D6 (0.67) | CYP2D6HRH1KCNH2HRH2CHRM1 | |
| SCHEMBL6419970 | 0.88 | CYP2D6 (0.69) | CYP2D6HRH1KCNH2HRH2CHRM1 | |
| SCHEMBL6419985 | 0.86 | CYP2D6 (0.65) | CYP2D6HRH1KCNH2HRH2CHRM1 | |
| SCHEMBL6275530 | 0.84 | HRH1 (1.00) | CYP2D6HRH1KCNH2HRH2CHRM1 | |
| SCHEMBL6279449 | 0.82 | HRH1 (0.84) | CYP2D6HRH1KCNH2HRH2CHRM1 | |
| SCHEMBL6415307 | 0.81 | CYP2D6 (0.72) | CYP2D6HRH1KCNH2HRH2CHRM1 | |
| SCHEMBL6414644 | 0.81 | HRH1 (0.72) | CYP2D6HRH1KCNH2HRH2CHRM1 | |
| SCHEMBL6276113 | 0.81 | HRH1 (0.82) | CYP2D6HRH1KCNH2HRH2CHRM1 | |
| SCHEMBL6269330 | 0.79 | CYP2D6 (0.61) | CYP2D6HRH1KCNH2HRH2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050277645-A1 | Sleep inducing compounds and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2005-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277645-A1 | Sleep inducing compounds and methods relating thereto | CNR1, CNR2, MTNR1B | CYP2D6 74/4885HRH1 104/4885KCNH2 1127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.