Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC5 | O15392 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.51 |
| ▸ | GAA | P10253 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6414866 | 1.00 | BIRC5 (0.54) | BIRC5KDM4EGAAMAPTNPC1 | |
| SCHEMBL6414735 | 0.93 | BIRC5 (0.57) | BIRC5KDM4EGAAMAPTNPC1 | |
| SCHEMBL6414740 | 0.93 | BIRC5 (0.57) | BIRC5KDM4EGAAMAPTNPC1 | |
| SCHEMBL6415955 | 0.91 | BIRC5 (0.67) | BIRC5KDM4EGAAMAPTNPC1 | |
| SCHEMBL6415953 | 0.91 | BIRC5 (0.67) | BIRC5KDM4EGAAMAPTNPC1 | |
| SCHEMBL6413614 | 0.91 | MAPT (0.46) | BIRC5KDM4EGAAMAPTNPC1 | |
| SCHEMBL6413618 | 0.91 | MAPT (0.46) | BIRC5KDM4EGAAMAPTNPC1 | |
| SCHEMBL6432249 | 0.90 | KDM4E (0.61) | BIRC5KDM4EGAAMAPTNPC1 | |
| SCHEMBL6414677 | 0.90 | BIRC5 (0.51) | BIRC5KDM4EGAAMAPTNPC1 | |
| SCHEMBL6414682 | 0.90 | BIRC5 (0.51) | BIRC5KDM4EGAAMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005044270-A1 | OXADIAZOLOPYRAZINE DERIVATIVES AS PHARMACEUTICALLY ACTIVE COMPOUNDS | 4SC AG (DE) | 2005-05-19 | — | — | WO | disclosed |
| EP-1529531-A1 | Oxadiazolopyrazine derivatives as pharmaceutically active compounds | 4SC AG (DE) | 2005-05-11 | — | — | EP | disclosed |