Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 9/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6409247 | 0.99 | CCR5 (0.51) | CCR5OPRL1MEN1KMT2ASLC6A4 | |
| SCHEMBL6410269 | 0.99 | CCR5 (0.51) | CCR5OPRL1MEN1KMT2ASLC6A4 | |
| Hydrochloric Acid SCHEMBL5252103 | 0.98 | CCR5 (0.50) | CCR5OPRL1MEN1KMT2ASLC6A4 | |
| SCHEMBL6408887 | 0.97 | CCR5 (0.51) | CCR5MEN1KMT2ASLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL6416381 | 0.96 | CCR5 (0.50) | CCR5MEN1KMT2ASLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL6408844 | 0.96 | CCR5 (0.50) | CCR5MEN1KMT2ASLC6A4SLC6A3 | |
| SCHEMBL6409448 | 0.90 | SLC6A4 (0.42) | CCR5KMT2ASLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL6413008 | 0.89 | CCR5 (0.56) | CCR5MEN1KMT2ASIGMAR1KCNH2 | |
| Hydrochloric Acid SCHEMBL6414819 | 0.89 | SLC6A4 (0.41) | CCR5KMT2ASLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL6416644 | 0.89 | SLC6A4 (0.41) | CCR5SLC6A4SLC6A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | CCR5 4/4885OPRL1 151/4885MEN1 4007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.