Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 5/20 | 0.65 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.53 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Z-Pro-Prolinal SCHEMBL7272251 | 0.94 | PREP (0.67) | PREPCTRB1NPSR1TSHRL3MBTL1 | |
| Z-Pro-Prolinal SCHEMBL1219336 | 0.94 | PREP (0.67) | PREPCTRB1NPSR1TSHRL3MBTL1 | |
| Z-Pro-Prolinal SCHEMBL1380758 | 0.94 | PREP (0.67) | PREPCTRB1NPSR1TSHRL3MBTL1 | |
| SCHEMBL8639445 | 0.91 | PREP (0.65) | PREPCTRB1NPSR1TSHRL3MBTL1 | |
| Z-Pro-Prolinal SCHEMBL8078128 | 0.90 | PREP (0.61) | PREPCTRB1NPSR1TSHRL3MBTL1 | |
| SCHEMBL2198876 | 0.84 | PREP (0.56) | PREPACE2CTRB1NPSR1TSHR | |
| SCHEMBL2195118 | 0.84 | PREP (0.56) | PREPACE2CTRB1NPSR1TSHR | |
| SCHEMBL2198909 | 0.84 | PREP (0.56) | PREPACE2CTRB1NPSR1TSHR | |
| SCHEMBL9702694 | 0.83 | PREP (0.62) | PREPCTRB1NPSR1TSHRL3MBTL1 | |
| SCHEMBL9702688 | 0.83 | PREP (0.62) | PREPCTRB1NPSR1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624307-B2 | Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs | THE GENERAL HOSPITAL CORPORATION (US) | 2017-04-18 | — | — | US | claimed |
| US-9352016-B2 | Factor XII inhibitors for the administration with medical procedures comprising contact with artificial surfaces | CSL BEHRING GMBH (DE) | 2016-05-31 | — | — | US | claimed |
| US-20140378653-A1 | Factor XII Inhibitors for the Treatment of Neurological Inflammatory Disorders | CSL LTD. (AU) | 2014-12-25 | — | — | US | claimed |
| EP-2809336-A1 | FACTOR XII INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL INFLAMMATORY DISORDERS | CSL Behring GmbH (DE) | 2014-12-10 | — | — | EP | claimed |
| US-20140072572-A1 | FACTOR XII INHIBITORS FOR THE TREATMENT OF SILENT BRAIN ISCHEMIA AND ISCHEMIA OF OTHER ORGANS | CSL BEHRING GMBH (DE) | 2014-03-13 | — | — | US | claimed |
| US-20140072600-A1 | FACTOR XII INHIBITORS FOR THE ADMINISTRATION WITH MEDICAL PROCEDURES COMPRISING CONTACT WITH ARTIFICIAL SURFACES | CSL BEHRING GMBH (DE) | 2014-03-13 | — | — | US | claimed |
| EP-2683397-A1 | FACTOR XII INHIBITORS FOR THE ADMINISTRATION WITH MEDICAL PROCEDURES COMPRISING CONTACT WITH ARTIFICIAL SURFACES | CSL Behring GmbH (DE) | 2014-01-15 | — | — | EP | claimed |
| EP-2683396-A1 | FACTOR XII INHIBITORS FOR THE TREATMENT OF SILENT BRAIN ISCHEMIA AND ISCHEMIA OF OTHER ORGANS | CSL Behring GmbH (DE) | 2014-01-15 | — | — | EP | claimed |
| WO-2013113774-A1 | FACTOR XII INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL INFLAMMATORY DISORDERS | CSL BEHRING GMBH (DE) | 2013-08-08 | — | — | WO | claimed |
| EP-2623110-A1 | Factor XII inhibitors for the treatment of neurological inflammatory disorders | CSL Behring GmbH (DE) | 2013-08-07 | — | — | EP | claimed |
| WO-2012120128-A1 | FACTOR XII INHIBITORS FOR THE ADMINISTRATION WITH MEDICAL PROCEDURES COMPRISING CONTACT WITH ARTIFICIAL SURFACES | CSL BEHRING GMBH (DE) | 2012-09-13 | — | — | WO | claimed |
| WO-2012120124-A1 | FACTOR XII INHIBITORS FOR THE TREATMENT OF SILENT BRAIN ISCHEMIA AND ISCHEMIA OF OTHER ORGANS | CSL BEHRING GMBH (DE) | 2012-09-13 | — | — | WO | claimed |
| EP-2497489-A1 | Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs | CSL Behring GmbH (DE) | 2012-09-12 | — | — | EP | claimed |
| US-20120148688-A1 | PREVENTION OF THROMBUS FORMATION AND/OR STABILIZATION | CSL BEHRING GMBH | 2012-06-14 | — | — | US | claimed |
| EP-2272565-A2 | Prevention of thrombus formation and/or stabilization | CSL Behring GmbH (DE) | 2011-01-12 | — | — | EP | claimed |
| US-20080254039-A1 | Prevention of Thrombus Formation and/or Stabilization | CSL BEHRING GMBH (DE) | 2008-10-16 | — | — | US | claimed |
| EP-1830924-A1 | PREVENTION OF THROMBUS FORMATION AND/OR STABILIZATION | CSL Behring GmbH (DE) | 2007-09-12 | — | — | EP | claimed |
| WO-2006066878-A1 | PREVENTION OF THROMBUS FORMATION AND/OR STABILIZATION | CSL BEHRING GMBH (DE) | 2006-06-29 | — | — | WO | claimed |
| US-11345759-B2 | Methods of administering inhibitory anti-factor XII/XIIa monoclonal antibodies | CSL BEHRING GMBH (DE) | 2022-05-31 | — | — | US | disclosed |
| WO-2006066878-A1 | PREVENTION OF THROMBUS FORMATION AND/OR STABILIZATION | CSL BEHRING GMBH (DE) | 2006-06-29 | — | — | WO | disclosed |