Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 5/20 | 0.65 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Z-Pro-Prolinal SCHEMBL1380758 | 0.98 | PREP (0.67) | PREPCTRB1NPSR1TSHRL3MBTL1 | |
| Z-Pro-Prolinal SCHEMBL7272251 | 0.98 | PREP (0.67) | PREPCTRB1NPSR1TSHRL3MBTL1 | |
| Z-Pro-Prolinal SCHEMBL1219336 | 0.98 | PREP (0.67) | PREPCTRB1NPSR1TSHRL3MBTL1 | |
| Z-Pro-Prolinal SCHEMBL641528 | 0.91 | PREP (0.65) | PREPCTRB1NPSR1TSHRL3MBTL1 | |
| SCHEMBL12490662 | 0.89 | SMN1; SMN2 (0.52) | PREPCTRB1 | |
| SCHEMBL2723657 | 0.89 | SMN1; SMN2 (0.52) | PREPCTRB1 | |
| SCHEMBL8790790 | 0.89 | SMN1; SMN2 (0.52) | PREPCTRB1 | |
| SCHEMBL2198876 | 0.88 | PREP (0.56) | PREPCTRB1NPSR1TSHRL3MBTL1 | |
| SCHEMBL2195118 | 0.88 | PREP (0.56) | PREPCTRB1NPSR1TSHRL3MBTL1 | |
| SCHEMBL2198909 | 0.88 | PREP (0.56) | PREPCTRB1NPSR1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |