Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GBA2 | Q9HCG7 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18498621 | 0.83 | LMNA (0.56) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL15974247 | 0.82 | LMNA (0.49) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL12715581 | 0.77 | NR1H2 (0.49) | SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4736587 | 0.77 | NR1H2 (0.49) | SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL1573438 | 0.77 | NR1H2 (0.49) | SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL1633241 | 0.77 | LMNA (0.56) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL1542778 | 0.77 | LMNA (0.49) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL19100435 | 0.76 | LMNA (0.46) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL14034308 | 0.75 | LMNA (0.48) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL14034326 | 0.75 | LMNA (0.48) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539783-A1 | INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018496-A1 | INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2004-03-04 | — | — | WO | disclosed |