Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.63 |
| ▸ | GSK3B | P49841 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | MRE11 | P49959 | 1/20 | 0.56 |
| ▸ | XDH | P47989 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CLK3 | P49761 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | MYC | P01106 | 1/20 | 0.49 |
| ▸ | IL1RN | P18510 | 1/20 | 0.49 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | NAT1 | P18440 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6415312 | 1.00 | GSK3A (0.63) | GSK3AGSK3BTDP1MRE11XDH | |
| SCHEMBL1250449 | 0.86 | TDP1 (0.76) | GSK3BTDP1AKR1B1MYCIL1RN | |
| SCHEMBL12892083 | 0.86 | TDP1 (0.76) | GSK3BTDP1AKR1B1MYCIL1RN | |
| SCHEMBL1250447 | 0.86 | TDP1 (0.76) | GSK3BTDP1AKR1B1MYCIL1RN | |
| SCHEMBL6416668 | 0.83 | MRE11 (0.70) | GSK3AGSK3BTDP1MRE11XDH | |
| SCHEMBL6416669 | 0.83 | MRE11 (0.70) | GSK3AGSK3BTDP1MRE11XDH | |
| SCHEMBL8186386 | 0.82 | AKR1B1 (0.74) | GSK3BTDP1MRE11XDHMEN1 | |
| SCHEMBL8186384 | 0.82 | AKR1B1 (0.74) | GSK3BTDP1MRE11XDHMEN1 | |
| SCHEMBL22971852 | 0.81 | XDH (0.75) | GSK3BTDP1MRE11XDHMEN1 | |
| SCHEMBL6721235 | 0.78 | GSK3B (1.00) | GSK3AGSK3BTDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050019825-A9 | Common ligand mimics: pseudothiohydantoins | TRIAD THERAPEUTICS, INC. | 2005-01-27 | — | — | US | disclosed |
| US-20040009527-A1 | Common ligand mimics: pseudothiohydantoins | DONG QING (US) | 2004-01-15 | — | — | US | disclosed |
| WO-2003081209-A2 | IDENTIFICATION OF LIGANDS FOR A RECEPTOR FAMILY AND RELATED METHODS | TRIAD THERAPEUTICS, INC. (US) | 2003-10-02 | — | — | WO | disclosed |
| US-20030180797-A1 | Identification of ligands for a receptor family and related methods | TRIAD THERAPEUTICS, INC. | 2003-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050019825-A9 | Common ligand mimics: pseudothiohydantoins | FGFR3, BID, FLT3 | GSK3A 3503/4885GSK3B 3537/4885TDP1 4871/4885 |
| US-20040009527-A1 | Common ligand mimics: pseudothiohydantoins | FGFR3, BID, FLT3 | GSK3A 3503/4885GSK3B 3537/4885TDP1 4871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.