Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 13/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.67 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.55 |
| ▸ | CHRNG | P07510 | 1/20 | 0.55 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.55 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.55 |
| ▸ | CHRND | Q07001 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6415945 | 1.00 | SLC6A3 (0.67) | SLC6A3SLC6A4CHRNA1CHRNGITGA5 | |
| SCHEMBL7038162 | 1.00 | SLC6A3 (0.67) | SLC6A3SLC6A4CHRNA1CHRNGITGA5 | |
| SCHEMBL6358433 | 0.87 | SLC6A3 (0.65) | SLC6A3SLC6A4CHRNA1CHRNGITGA5 | |
| SCHEMBL6356628 | 0.87 | SLC6A3 (0.65) | SLC6A3SLC6A4CHRNA1CHRNGITGA5 | |
| SCHEMBL7033330 | 0.87 | SLC6A3 (0.65) | SLC6A3SLC6A4CHRNA1CHRNGITGA5 | |
| SCHEMBL6356631 | 0.87 | SLC6A3 (0.65) | SLC6A3SLC6A4CHRNA1CHRNGITGA5 | |
| SCHEMBL4132405 | 0.84 | SLC6A3 (0.49) | SLC6A3SLC6A4 | |
| SCHEMBL4132407 | 0.84 | SLC6A3 (0.49) | SLC6A3SLC6A4 | |
| SCHEMBL4133259 | 0.84 | SLC6A3 (0.49) | SLC6A3SLC6A4 | |
| SCHEMBL4139225 | 0.84 | SLC6A3 (0.49) | SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670375-B2 | Particularly, 8-aza-, 8-carbo- and 8-oxo- tropanes having 6-or 7-substituents; preferred are the dopamine transporter, the serotonin transporter and the norepinephrine transporter. | ORGANIX, INC. | 2003-12-30 | — | — | US | claimed |
| EP-1493744-A1 | Tropane analogs and methods for inhibition of monoamine transport | ORGANIX, INC. (US) | 2005-01-05 | — | — | EP | disclosed |
| EP-0996619-B1 | TROPANE ANALOGS AND METHODS FOR INHIBITION OF MONOAMINE TRANSPORT | ORGANIX INC (US) | 2005-01-05 | — | — | EP | disclosed |
| EP-0996619-A1 | TROPANE ANALOGS AND METHODS FOR INHIBITION OF MONOAMINE TRANSPORT | ORGANIX, INC. (US) | 2000-05-03 | — | — | EP | disclosed |
| WO-1999002526-A1 | TROPANE ANALOGS AND METHODS FOR INHIBITION OF MONOAMINE TRANSPORT | ORGANIX, INC. (US) | 1999-01-21 | — | — | WO | disclosed |