Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 2/20 | 0.52 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 11/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 10/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6707710 | 0.95 | KLK7 (0.52) | KLK7KLK5SIRT2SIRT1SIRT5 | |
| SCHEMBL6707708 | 0.95 | KLK7 (0.52) | KLK7KLK5SIRT2SIRT1SIRT5 | |
| SCHEMBL12518250 | 0.84 | KLK7 (0.56) | KLK7KLK5SIRT2SIRT1SIRT5 | |
| SCHEMBL6876847 | 0.83 | HDAC1 (0.47) | KLK7KLK5SIRT2SIRT1SIRT5 | |
| SCHEMBL12514745 | 0.83 | KLK7 (0.55) | KLK7KLK5SIRT2SIRT1SIRT5 | |
| SCHEMBL19219892 | 0.82 | KLK7 (0.54) | KLK7KLK5SIRT2SIRT1SIRT5 | |
| SCHEMBL5654684 | 0.82 | SIRT5 (0.55) | KLK7KLK5SIRT2SIRT1SIRT5 | |
| SCHEMBL13973839 | 0.81 | KLK7 (0.54) | KLK7KLK5SIRT2SIRT1SIRT5 | |
| SCHEMBL5970447 | 0.81 | SIRT5 (0.60) | SIRT2SIRT1SIRT5HDAC4HDAC1 | |
| SCHEMBL12518233 | 0.80 | KLK7 (0.52) | KLK7KLK5SIRT2SIRT1SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849757-B2 | Antiangiogenic drug to treat cancer, arthritis and retinopathy | ABBOTT LABORATORIES (US) | 2005-02-01 | — | — | US | disclosed |
| US-20040110959-A1 | Antiangiogenic drug to treat cancer, arthritis and retinopathy | ABBVIE INC. | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110959-A1 | Antiangiogenic drug to treat cancer, arthritis and retinopathy | FLT1, VEGFA, KDR | KLK7 2815/4885KLK5 2344/4885SIRT2 1214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.