Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | RARB | P10826 | 3/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL642659 | 0.88 | LMNA (0.52) | LMNASTAT3SMN1; SMN2RARBNR1H4 | |
| SCHEMBL641557 | 0.85 | LMNA (0.55) | LMNASTAT3SMN1; SMN2RARBNR1H4 | |
| SCHEMBL644604 | 0.83 | SMN1; SMN2 (0.56) | LMNASTAT3SMN1; SMN2RARBNR1H4 | |
| SCHEMBL643560 | 0.82 | SMN1; SMN2 (0.58) | LMNASTAT3SMN1; SMN2RARBNR1H4 | |
| SCHEMBL641483 | 0.82 | SMN1; SMN2 (0.57) | LMNASTAT3SMN1; SMN2RARBNR1H4 | |
| SCHEMBL641396 | 0.80 | LMNA (0.52) | LMNASTAT3SMN1; SMN2RARBNR1H4 | |
| SCHEMBL643445 | 0.80 | SMN1; SMN2 (0.59) | LMNASTAT3SMN1; SMN2RARBNR1H4 | |
| SCHEMBL9161294 | 0.79 | SMN1; SMN2 (0.64) | LMNASTAT3SMN1; SMN2NR1H4MAPT | |
| SCHEMBL641683 | 0.79 | LMNA (0.51) | LMNASTAT3SMN1; SMN2RARBNR1H4 | |
| SCHEMBL642514 | 0.78 | SMN1; SMN2 (0.50) | LMNASTAT3SMN1; SMN2RARBNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057173-B1 | AMIDES AS SPHINGOMYELINE INHIBITORS | NOVARTIS AG (CH) | 2014-02-26 | — | — | EP | claimed |
| US-8119617-B2 | aSMase inhibitors | NOVARTIS AG (CH) | 2012-02-21 | — | — | US | claimed |
| EP-2057173-A1 | AMIDES AS SPHINGOMYELINE INHIBITORS | Novartis AG (CH) | 2009-05-13 | — | — | EP | claimed |
| WO-2008022771-A1 | AMIDES AS SPHINGOMYELINE INHIBITORS | NOVARTIS AG (CH) | 2008-02-28 | — | — | WO | claimed |
| EP-2057173-B1 | AMIDES AS SPHINGOMYELINE INHIBITORS | NOVARTIS AG (CH) | 2014-02-26 | — | — | EP | disclosed |
| EP-2057173-A1 | AMIDES AS SPHINGOMYELINE INHIBITORS | Novartis AG (CH) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008022771-A1 | AMIDES AS SPHINGOMYELINE INHIBITORS | NOVARTIS AG (CH) | 2008-02-28 | — | — | WO | disclosed |