SCHEMBL6417593

SCHEMBL6417593

CCCCOC(=O)c1c2nc(c(C(=O)OCCCC)c3ccc([nH]3)c(C(=O)OCCCC)c3nc(c(C(=O)OCCCC)c4ccc1[nH]4)C=C3)C=C2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 7/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
ALDH1A1 P00352 6/20 0.45
CYP1A2 P05177 3/20 0.45
CYP2C19 P33261 3/20 0.45
CYP3A4 P08684 3/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
CYP2C9 P11712 2/20 0.45
KDM4E B2RXH2 2/20 0.45
MAPT P10636 1/20 0.45
HPGD P15428 1/20 0.45
LMNA P02545 4/20 0.44
ESR1 P03372 2/20 0.44
MAPK1 P28482 2/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
CYP2D6 P10635 1/20 0.44
NR1H2 P55055 1/20 0.44
RNASEL Q05823 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6412627 0.95 NPC1 (0.49) TSHRL3MBTL1TDP1ALDH1A1CYP1A2
SCHEMBL6418036 0.95 NPC1 (0.49) TSHRL3MBTL1TDP1ALDH1A1CYP1A2
SCHEMBL6417625 0.91 ALDH1A1 (0.44) TSHRTDP1ALDH1A1CYP1A2CYP2C19
SCHEMBL6414909 0.85 ALDH1A1 (0.41) TSHRL3MBTL1TDP1ALDH1A1CYP1A2
SCHEMBL6421359 0.77 ABCG2 (0.61) ALDH1A1KDM4EHPGDLMNAMEN1
SCHEMBL6441331 0.76 SIRT2 (0.41) L3MBTL1ALDH1A1CYP1A2SMN1; SMN2KDM4E
SCHEMBL27255483 0.76 TOP1 (0.67) TSHRCYP1A2CYP2C19CYP3A4SMN1; SMN2
SCHEMBL6413625 0.75 STAT3 (0.38) TSHRTDP1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL12190736 0.75 TOP1 (0.55) TSHRALDH1A1CYP1A2CYP2C19SMN1; SMN2
SCHEMBL7704554 0.74 ABCG2 (0.49) TSHRALDH1A1CYP1A2CYP2C19CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1071474-B1 SUBSTITUTED PORPHYRINS UNIV DUKE (US) 2005-11-30 EP disclosed
US-6479477-B1 SUITABLE FOR USE IN MODULATING INTRA- AND EXTRACELLULAR PROCESSES IN WHICH SUPEROXIDE RADICALS, OR OTHER OXIDANTS SUCH AS HYDROGEN PEROXIDE OR PEROXYNITRITE, ARE A PARTICIPANT DUKE UNIVERSITY 2002-11-12 US disclosed
WO-1999055388-A9 SUBSTITUTED PORPHYRINS UNIV DUKE (US) 2000-01-27 WO disclosed