Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | HCN1 | O60741 | 7/20 | 0.43 |
| ▸ | HCN4 | Q9Y3Q4 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | HCN3 | Q9P1Z3 | 1/20 | 0.41 |
| ▸ | HCN2 | Q9UL51 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2402277 | 0.90 | NPSR1 (0.48) | NPSR1CHRM2CHRM3NOD2HTT | |
| SCHEMBL2400946 | 0.81 | NPSR1 (0.56) | NPSR1CHRM2CHRM3NOD2HTT | |
| SCHEMBL15309109 | 0.77 | NPSR1 (0.60) | NPSR1CHRM2CHRM3NOD2HTT | |
| SCHEMBL6409354 | 0.74 | HTR1A (0.44) | LMNATSHR | |
| SCHEMBL2399133 | 0.74 | AVPR1A (0.45) | CHRM2HTTLMNA | |
| SCHEMBL11715064 | 0.73 | NPSR1 (0.81) | NPSR1CHRM2CHRM3NOD2HTT | |
| SCHEMBL2400710 | 0.73 | ATM (0.43) | HTTTDP1SMN1; SMN2 | |
| SCHEMBL2403591 | 0.72 | MAPK8 (0.57) | — | |
| SCHEMBL2399175 | 0.72 | KMT2A (0.47) | LMNAKDM4E | |
| SCHEMBL2399883 | 0.72 | MAPT (0.48) | NPSR1HTTTSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |