Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9481728 | 0.85 | NPC1 (0.47) | PTPN1GSK3BCES1HDAC1HDAC8 | |
| SCHEMBL313060 | 0.84 | PTPN1 (0.62) | PTPN1GSK3BMMP1CES2CES1 | |
| SCHEMBL29987081 | 0.83 | PTPN1 (0.75) | PTPN1GSK3BMMP1CES2CES1 | |
| SCHEMBL4974963 | 0.81 | NPSR1 (0.60) | CES2HDAC1ALDH1A1HDAC3HDAC2 | |
| SCHEMBL527362 | 0.80 | PLOD2 (0.55) | PTPN1CES2CES1HSD11B1MAPT | |
| SCHEMBL3569892 | 0.80 | PTPN1 (0.66) | PTPN1GSK3BMMP1CES2CES1 | |
| SCHEMBL18860300 | 0.79 | PTPN1 (0.59) | PTPN1GSK3BMMP1CES2CES1 | |
| SCHEMBL1643579 | 0.78 | PTPN1 (0.73) | PTPN1GSK3BMMP1CES2CES1 | |
| SCHEMBL28485298 | 0.78 | NPC1 (0.60) | GSK3BCES2CES1HDAC1HDAC8 | |
| SCHEMBL830420 | 0.77 | PTPN1 (0.62) | PTPN1GSK3BMMP1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043341-A1 | 3-'Hydroxy-(-4-trifluoromethylphenyl)-methyl-7-spirocyclobutyl-5,6,7 8-tetrahydroquinolin-5-ol derivatives and the use of the same as cholesterol ester transfer protein (cetp) inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-02-24 | — | — | US | disclosed |
| EP-1434581-A1 | 3- HYDROXY-(-4-TRIFLUOROMETHYLPHENYL)-METHYL-7-SPIROCYCLOBUTYL-5,6,7,8-TETRAHYDROQUINOLIN-5-OL DERIVATIVES AND THE USE OF THE SAME AS CHOLESTEROL ESTER TRANSFER PROTEIN (CETP) INHIBITORS | Bayer HealthCare AG (DE) | 2004-07-07 | — | — | EP | disclosed |
| WO-2003028727-A9 | 3-`HYDROXY-(-4-TRIFLUOROMETHYLPHENYL)-METHYL-7-SPIROCYCLOBUTYL-5,6,7,8-TETRAHYDROQUINOLIN-5-OL DERIVATIVES AND THE USE OF THE SAME AS CHOLESTEROL ESTER TRANSFER PROTEIN (CETP) INHIBITORS | BAYER AG (DE) | 2003-11-13 | — | — | WO | disclosed |
| WO-2003028727-A1 | 3-`HYDROXY-(-4-TRIFLUOROMETHYLPHENYL)-METHYL-7-SPIROCYCLOBUTYL-5,6,7,8-TETRAHYDROQUINOLIN-5-OL DERIVATIVES AND THE USE OF THE SAME AS CHOLESTEROL ESTER TRANSFER PROTEIN (CETP) INHIBITORS | BAYER HEALTHCARE AG (DE) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043341-A1 | 3-'Hydroxy-(-4-trifluoromethylphenyl)-methyl-7-spirocyclobutyl-5,6,7 8-tetrahydroquinolin-5-ol derivatives and the use of the same as cholesterol ester transfer protein (cetp) inhibitors | CETP, MTTP, HDLBP | PTPN1 4645/4885GSK3B 1260/4885MMP1 4267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.