Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.50 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.50 |
| ▸ | SLC22A3 | O75751 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18350824 | 0.91 | MEN1 (0.62) | MEN1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL3309754 | 0.90 | POLB (0.60) | MEN1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL30808659 | 0.90 | POLB (0.60) | MEN1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL8025555 | 0.90 | HTR2A (0.60) | MEN1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL18888413 | 0.85 | MEN1 (0.72) | MEN1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL7603769 | 0.82 | SLC6A2 (0.58) | MEN1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL15486077 | 0.81 | KDM4E (0.55) | MEN1KMT2AMAPTPOLBKDM4E | |
| Hydrochloric Acid SCHEMBL7810034 | 0.81 | SLC6A2 (0.59) | MEN1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL4733904 | 0.81 | SLC6A4 (0.65) | MEN1KMT2AMAPTKDM4ETDP1 | |
| SCHEMBL18350826 | 0.81 | MEN1 (0.51) | MEN1KMT2AMAPTPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6908926-B1 | Substituted imidazoles, their preparation and use | NOVO NORDISK A/S (DK) | 2005-06-21 | — | — | US | disclosed |
| US-6569849-B1 | N-Substituted azaheterocyclic compounds | NOVO NORDISK A/S (DK) | 2003-05-27 | — | — | US | disclosed |
| EP-1173438-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000063208-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-10-26 | — | — | WO | disclosed |
| EP-0934306-A1 | N-SUBSTITUTED AZAHETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998015546-A1 | N-SUBSTITUTED AZAHETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1998-04-16 | — | — | WO | disclosed |