Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 2/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3439556 | 0.83 | KDM4E (0.52) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL2597731 | 0.80 | KDM4E (0.50) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL157552 | 0.80 | KDM4E (0.50) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL2597732 | 0.80 | KDM4E (0.50) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL20508886 | 0.75 | — | — | |
| SCHEMBL2991432 | 0.75 | — | — | |
| SCHEMBL6575662 | 0.75 | — | — | |
| SCHEMBL23829504 | 0.74 | MME (0.36) | KDM4EMAPTACEMME | |
| SCHEMBL5003607 | 0.73 | KDM4E (0.47) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL4319221 | 0.73 | KDM4E (0.47) | KDM4EMAPTTHRBALOX15NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313738-A4 | PROCESS FOR THE PREPARATION AND PURIFICATION OF THIOL-CONTAINING MAYTANSINOIDS | IMMUNOGEN INC (US) | 2005-01-19 | — | — | EP | disclosed |
| EP-1313738-A1 | PROCESS FOR THE PREPARATION AND PURIFICATION OF THIOL-CONTAINING MAYTANSINOIDS | Immunogen, Inc. (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002016368-A1 | PROCESS FOR THE PREPARATION AND PURIFICATION OF THIOL-CONTAINING MAYTANSINOIDS | IMMUNOGEN, INC. (US) | 2002-02-28 | — | — | WO | disclosed |