Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6416479 | 0.82 | KDM4E (0.35) | MEN1KMT2AALDH1A1KDM4ENTRK1 | |
| SCHEMBL10998952 | 0.76 | KDM4E (0.35) | MEN1KMT2AALDH1A1KDM4ENTRK1 | |
| SCHEMBL28300418 | 0.76 | KDM4E (0.42) | MEN1KMT2AALDH1A1KDM4ENTRK1 | |
| SCHEMBL29533105 | 0.76 | KDM4E (0.35) | MEN1KMT2AALDH1A1KDM4ENTRK1 | |
| SCHEMBL11812742 | 0.73 | MEN1 (0.39) | MEN1KMT2AALDH1A1KDM4ENTRK1 | |
| SCHEMBL27361537 | 0.72 | CDK1 (0.46) | MEN1KMT2AKDM4EIGF1RCA2 | |
| SCHEMBL29991317 | 0.72 | CDK1 (0.46) | MEN1KMT2AKDM4EIGF1RCA2 | |
| SCHEMBL19212800 | 0.72 | MEN1 (0.40) | MEN1KMT2AALDH1A1KDM4ESYK | |
| SCHEMBL19744259 | 0.71 | MAPT (0.39) | MEN1KMT2ANTRK1MAPT | |
| SCHEMBL29991645 | 0.71 | KMT2A (0.50) | MEN1KMT2AKDM4EIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565475-A1 | DIAZINOPYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004046152-A1 | DIAZINOPYRIMIDINES | F. HOFFMANN LA ROCHE AG (CH) | 2004-06-03 | — | — | WO | disclosed |