Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | SPR | P35270 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17893461 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9AMAPTPDPK1PARP1 | |
| SCHEMBL20458014 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9AMAPTPDPK1PARP1 | |
| SCHEMBL20458007 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9AMAPTPDPK1PARP1 | |
| SCHEMBL5068159 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9AMAPTPDPK1PARP1 | |
| SCHEMBL1369682 | 0.78 | SMN1; SMN2 (0.62) | SMN1; SMN2RAB9AMAPTPDPK1PARP1 | |
| SCHEMBL13461924 | 0.77 | ALDH1A1 (0.54) | SMN1; SMN2RAB9AMAPTL3MBTL1CASP3 | |
| SCHEMBL18689714 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9AMAPTPDPK1PARP1 | |
| SCHEMBL18701479 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9AMAPTPDPK1PARP1 | |
| SCHEMBL3985339 | 0.74 | RXFP1 (0.54) | SMN1; SMN2RAB9AMAPTL3MBTL1CASP3 | |
| SCHEMBL13947840 | 0.74 | HTT (0.59) | SMN1; SMN2RAB9AMAPTL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603881-A2 | SUBSTITUTED THIOPHENES WITH ANTIBACTERIAL ACTIVITY | Replidyne, Inc. (US) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004078119-A2 | SUBSTITUTED THIOPHENES WITH ANTIBACTERIAL ACTIVITY | REPLIDYNE INC. (US) | 2004-09-16 | — | — | WO | disclosed |