Sugi Predict

Sugi Predict / Compounds / SCHEMBL642147

SCHEMBL642147

SCHEMBL642147

Cc1ccc(NC(=O)c2cc(Oc3ccc(S(C)(=O)=O)cc3)cc3c2CCO3)nc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GCK P35557 4/20 0.58
▸ NPC1 O15118 8/20 0.47
▸ RAB9A P51151 8/20 0.47
▸ TP53 P04637 2/20 0.45
▸ GAA P10253 2/20 0.45
▸ MITF O75030 1/20 0.45
▸ RXFP1 Q9HBX9 2/20 0.44
▸ KCNH2 Q12809 1/20 0.43
▸ KMT2A Q03164 1/20 0.42
▸ CYP1A2 P05177 1/20 0.41
▸ CYP3A4 P08684 1/20 0.41
▸ CYP2C9 P11712 1/20 0.41
▸ PKM P14618 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ KDM4E B2RXH2 2/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ GLA P06280 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ SORT1 Q99523 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL643441 0.86 GCK (0.59) GCKNPC1RAB9ATP53GAA
SCHEMBL642683 0.85 GCK (0.56) GCKNPC1RAB9ATP53GAA
SCHEMBL642084 0.79 GCK (0.59) GCKNPC1RAB9ATP53GAA
SCHEMBL644705 0.78 ALDH1A1 (0.39) GCKCYP2C9PKMKDM4EALDH1A1
SCHEMBL2645071 0.78 POLB (0.40) GCKCYP1A2CYP2C9L3MBTL1ALDH1A1
SCHEMBL643664 0.73 GCK (0.58) GCKNPC1RAB9ATP53GAA
SCHEMBL643682 0.72 GCK (0.57) GCKNPC1RAB9ATP53GAA
SCHEMBL645206 0.71 TSHR (0.41) GCKNPC1RAB9ATP53GAA
SCHEMBL643496 0.70 GCK (0.40) GCKKCNH2
SCHEMBL15780547 0.70 GCK (0.58) GCKNPC1RAB9AKCNH2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8119624-B2 Fused phenyl amido heterocyclic compounds PFIZER INC. (US) 2012-02-21 — — US disclosed
US-8119624-B2 Fused phenyl amido heterocyclic compounds PFIZER INC. (US) 2012-02-21 — — US disclosed
US-8119624-B2 Fused phenyl amido heterocyclic compounds PFIZER INC. (US) 2012-02-21 — — US disclosed
US-20110039821-A1 Fused Phenyl Amido Heterocyclic Compounds PFIZER INC 2011-02-17 — — US disclosed
US-20110039821-A1 Fused Phenyl Amido Heterocyclic Compounds PFIZER INC 2011-02-17 — — US disclosed
US-20110039821-A1 Fused Phenyl Amido Heterocyclic Compounds PFIZER INC 2011-02-17 — — US disclosed
US-7842713-B2 Fused phenyl amido heterocyclic compounds PFIZER INC (US) 2010-11-30 — — US disclosed
US-7842713-B2 Fused phenyl amido heterocyclic compounds PFIZER INC (US) 2010-11-30 — — US disclosed
US-20080280875-A1 FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS PFIZER INC. 2008-11-13 — — US disclosed
US-20080280875-A1 FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS PFIZER INC. 2008-11-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110039821-A1 Fused Phenyl Amido Heterocyclic Compounds GCK, GCKR, HK1 GCK 1/4885NPC1 1969/4885RAB9A 2949/4885
US-20080280875-A1 FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS GCK, GCKR, HK1 GCK 1/4885NPC1 1969/4885RAB9A 2949/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.