Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 12/20 | 0.54 |
| ▸ | ITGB6 | P18564 | 9/20 | 0.44 |
| ▸ | ITGB8 | P26012 | 7/20 | 0.44 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6421661 | 1.00 | ITGAV (0.54) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL6424882 | 0.87 | ITGAV (0.60) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL6424883 | 0.87 | ITGAV (0.60) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL6108062 | 0.85 | ITGAV (0.56) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL6108060 | 0.85 | ITGAV (0.56) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL18105066 | 0.77 | ITGAV (0.60) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL20091226 | 0.77 | ITGAV (0.60) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL6421979 | 0.76 | ITGAV (0.74) | ITGAVITGB3ITGB6ITGB8 | |
| SCHEMBL6421975 | 0.76 | ITGAV (0.74) | ITGAVITGB3ITGB6ITGB8 | |
| SCHEMBL6423958 | 0.76 | ITGAV (0.74) | ITGAVITGB3ITGB6ITGB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040098-B1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2005-04-27 | — | — | EP | disclosed |
| US-6297249-B1 | SUBSTITUTED 2-CARBOXYALKYLPYRIDINES | MERCK & CO., INC. | 2001-10-02 | — | — | US | disclosed |
| US-6048861-A | OSTEOPOROSIS; BONE DISORDERS; CARDIOVASCULAR DISORDERS; ANTIINFLAMMATROY AGENTS; WOUND HEALING AGENTS | MERCK & CO., INC. (US) | 2000-04-11 | — | — | US | disclosed |