Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224846 | 0.82 | MEN1 (0.51) | MEN1KMT2ANPC1ALDH1A1IDO1 | |
| SCHEMBL14567926 | 0.76 | MEN1 (0.45) | MEN1KMT2ANPC1ALDH1A1IDO1 | |
| SCHEMBL27583393 | 0.76 | MEN1 (0.56) | MEN1KMT2ANPC1ALDH1A1IDO1 | |
| SCHEMBL14048753 | 0.72 | MEN1 (0.56) | MEN1KMT2ANPC1ALDH1A1IDO1 | |
| SCHEMBL21776257 | 0.72 | MEN1 (0.56) | MEN1KMT2ANPC1ALDH1A1IDO1 | |
| SCHEMBL14198296 | 0.70 | HSD17B10 (0.52) | MEN1KMT2ANPC1ALDH1A1GAA | |
| SCHEMBL27466534 | 0.70 | MEN1 (0.40) | MEN1KMT2ANPC1ALDH1A1GAA | |
| SCHEMBL7685391 | 0.70 | ALDH1A1 (0.45) | MEN1KMT2ANPC1ALDH1A1IDO1 | |
| SCHEMBL3624232 | 0.69 | MEN1 (0.96) | MEN1KMT2ANPC1ALDH1A1IDO1 | |
| SCHEMBL4371802 | 0.68 | GAA (0.46) | GAACREBBPBRD4HTR2CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| CN-1168716-C | Optically active tetrahydrobenzindole derivative | 明治制果株式会社 | 2004-09-29 | — | — | CN | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| US-6407112-B1 | 2A,3,4,5-TETRAHYDRO-1H-BENZ(CD)INDOL-2-ONE DERIVATIVES; 5-HYDROXYTRYPTAMINE AGONISTS; SLEEP, CIRCADIAN RHYTHYM, BIPOLAR, AND PSYCHOLOGICAL DISORDER TREATMENT | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-06-18 | — | — | US | disclosed |
| CN-1306510-A | Optical active tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA (JP) | 2001-08-01 | — | — | CN | disclosed |
| EP-1081136-A1 | OPTICALLY ACTIVE TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2001-03-07 | — | — | EP | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |