Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 12/20 | 0.73 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | STS | P08842 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405918 | 0.87 | MTNR1B (0.54) | MTNR1BMTNR1ANPC1RAB9A | |
| SCHEMBL5871858 | 0.86 | MTNR1B (0.86) | MTNR1BMTNR1A | |
| SCHEMBL6408595 | 0.86 | MTNR1B (0.56) | MTNR1BMTNR1ANPC1RAB9A | |
| SCHEMBL2261060 | 0.85 | MTNR1B (0.53) | MTNR1BMTNR1AALDH1A1NPC1RAB9A | |
| SCHEMBL6409459 | 0.85 | MTNR1B (0.54) | MTNR1BMTNR1ANPC1RAB9A | |
| SCHEMBL2259511 | 0.85 | MTNR1B (0.53) | MTNR1BMTNR1ANPC1RAB9A | |
| SCHEMBL8649814 | 0.84 | MTNR1B (1.00) | MTNR1BMTNR1AALDH1A1 | |
| SCHEMBL8655497 | 0.83 | MTNR1B (0.79) | MTNR1BMTNR1A | |
| SCHEMBL6423382 | 0.83 | CHRNA7 (0.51) | MTNR1BNPC1RAB9A | |
| SCHEMBL6407452 | 0.83 | MTNR1B (0.52) | MTNR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |