Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | TSPO | P30536 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6421542 | 0.92 | HDAC1 (0.55) | HDAC6HDAC1KDM4EHSD17B10MEN1 | |
| Trifluoroacetic Acid SCHEMBL6424059 | 0.88 | HDAC6 (0.52) | HDAC6HDAC1KDM4EHSD17B10MEN1 | |
| Trifluoroacetic Acid SCHEMBL6425706 | 0.86 | HDAC6 (0.52) | HDAC6HDAC1KDM4EHSD17B10MEN1 | |
| Trifluoroacetic Acid SCHEMBL6421107 | 0.85 | HDAC6 (0.52) | HDAC6HDAC1KDM4EHSD17B10MEN1 | |
| Trifluoroacetic Acid SCHEMBL6422705 | 0.85 | HDAC6 (0.52) | HDAC6HDAC1KDM4EHSD17B10MEN1 | |
| SCHEMBL5616812 | 0.83 | HDAC1 (0.55) | HDAC6HDAC1KDM4EHSD17B10MEN1 | |
| Hydrochloric Acid SCHEMBL6475095 | 0.83 | KDM4E (0.54) | HDAC6HDAC1KDM4EHSD17B10MEN1 | |
| Trifluoroacetic Acid SCHEMBL6423027 | 0.83 | HDAC6 (0.67) | HDAC6HDAC1HTR6HDAC8 | |
| Trifluoroacetic Acid SCHEMBL6421091 | 0.81 | HDAC6 (0.51) | HDAC6HDAC1KDM4EHSD17B10MEN1 | |
| Trifluoroacetic Acid SCHEMBL968555 | 0.80 | HTR2A (0.60) | HDAC6HDAC1KDM4EHSD17B10HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |