Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.34 |
| ▸ | PLK4 | O00444 | 5/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.34 |
| ▸ | LCK | P06239 | 5/20 | 0.34 |
| ▸ | FYN | P06241 | 5/20 | 0.34 |
| ▸ | CSF1R | P07333 | 5/20 | 0.34 |
| ▸ | LYN | P07948 | 5/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.34 |
| ▸ | SRC | P12931 | 5/20 | 0.34 |
| ▸ | FLT1 | P17948 | 5/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.34 |
| ▸ | FLT4 | P35916 | 5/20 | 0.34 |
| ▸ | FLT3 | P36888 | 5/20 | 0.34 |
| ▸ | BLK | P51451 | 5/20 | 0.34 |
| ▸ | NEK2 | P51955 | 5/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6422871 | 1.00 | KDR (0.34) | KDRAURKBPLK4PRKD3MAP4K4 | |
| SCHEMBL6422863 | 0.83 | KDR (0.48) | KDRAURKBPLK4PRKD3MAP4K4 | |
| SCHEMBL6422866 | 0.83 | KDR (0.48) | KDRAURKBPLK4PRKD3MAP4K4 | |
| SCHEMBL6422550 | 0.78 | KDR (0.49) | KDRAURKBPLK4PRKD3MAP4K4 | |
| SCHEMBL6422553 | 0.78 | KDR (0.49) | KDRAURKBPLK4PRKD3MAP4K4 | |
| SCHEMBL6425057 | 0.77 | BTK (0.57) | KDRBTK | |
| SCHEMBL3526338 | 0.76 | KDR (0.43) | KDRAURKBPLK4PRKD3MAP4K4 | |
| SCHEMBL3531482 | 0.74 | EPHB4 (0.36) | KDRAURKBPLK4PRKD3MAP4K4 | |
| SCHEMBL3534022 | 0.74 | LCK (0.41) | KDRAURKBPLK4PRKD3MAP4K4 | |
| SCHEMBL3534023 | 0.74 | LCK (0.41) | KDRAURKBPLK4PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050026944-A1 | Thienopyridine and furopyridine kinase inhibitors | ABBOTT LABORATORIES | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026944-A1 | Thienopyridine and furopyridine kinase inhibitors | ABL1, ERBB2, LCK | KDR 494/4885AURKB 171/4885PLK4 442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.