SCHEMBL6423218

SCHEMBL6423218

NN[C@@H](Cc1ccccc1)C(N)=O

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 1/20 0.55
HPGDS O60760 4/20 0.50
GNPAT O15228 1/20 0.50
ALPI P09923 1/20 0.50
PKM P14618 1/20 0.50
PTGS1 P23219 1/20 0.50
XIAP P98170 1/20 0.50
SLC7A5 Q01650 1/20 0.50
ELANE P08246 1/20 0.49
CYP1A2 P05177 1/20 0.48
FCER2 P06734 2/20 0.48
MMP1 P03956 1/20 0.48
KMT2A Q03164 1/20 0.48
MME P08473 1/20 0.47
NPSR1 Q6W5P4 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9391159 1.00 EPHX1 (0.55) EPHX1HPGDSGNPATALPIPKM
SCHEMBL9109075 0.87 HPGDS (0.56) EPHX1HPGDSFCER2MMP1MME
SCHEMBL17598277 0.87 GNPAT (0.56) EPHX1GNPATALPIPKMPTGS1
SCHEMBL412958 0.86 GNPAT (0.58) GNPATALPIPKMPTGS1XIAP
SCHEMBL93439 0.86 GNPAT (0.58) GNPATALPIPKMPTGS1XIAP
SCHEMBL5694618 0.86 GNPAT (0.58) GNPATALPIPKMPTGS1XIAP
SCHEMBL93440 0.86 GNPAT (0.58) GNPATALPIPKMPTGS1XIAP
SCHEMBL1803033 0.85 EPHX1 (0.55) EPHX1HPGDSALPIPKMPTGS1
SCHEMBL18494069 0.85 EPHX1 (0.55) EPHX1HPGDSALPIPKMPTGS1
SCHEMBL5721934 0.85 EPHX1 (0.55) EPHX1HPGDSALPIPKMPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0989982-B1 BARBITURIC ACID DERIVATIVES WITH ANTIMETASTATIC AND ANTITUMOR ACTIVITY ROCHE DIAGNOSTICS GMBH (DE) 2005-08-17 EP claimed
EP-0989982-A1 BARBITURIC ACID DERIVATIVES WITH ANTIMETASTATIC AND ANTITUMOR ACTIVITY Roche Diagnostics GmbH (DE) 2000-04-05 EP disclosed
WO-1998058925-A1 BARBITURIC ACID DERIVATIVES WITH ANTIMETASTATIC AND ANTITUMOR ACTIVITY ROCHE DIAGNOSTICS GMBH (DE) 1998-12-30 WO disclosed
WO-1994018229-A1 1,2,4-TRIAZINONE DERIVATIVES AND THEIR USE IN THERAPY FISONS CORPORATION (US) 1994-08-18 WO disclosed
EP-0193083-A1 Anti-tumoral(1-arylmethyl-ethylene diamine)-platinum(II)-complexes ASTA Pharma AG (DE) 1986-09-03 EP disclosed