Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | SMO | Q99835 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.45 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.45 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555269 | 0.83 | HDAC6 (0.54) | HDAC6ESR2NR1H2BRD4CREBBP | |
| SCHEMBL743782 | 0.83 | HDAC6 (0.54) | HDAC6ESR2NR1H2BRD4CREBBP | |
| SCHEMBL2370518 | 0.83 | ESR2 (0.54) | USP2SMN1; SMN2HDAC6ESR2NR1H2 | |
| SCHEMBL6421478 | 0.82 | NR1H2 (0.54) | HDAC6ESR2NR1H2BRD4CREBBP | |
| SCHEMBL978284 | 0.82 | HDAC6 (0.59) | SMN1; SMN2HDAC6ESR2NR1H2BRD4 | |
| SCHEMBL1174513 | 0.81 | HDAC6 (0.72) | HDAC6ESR2NR1H2BRD4CREBBP | |
| SCHEMBL6422061 | 0.81 | NR1H2 (0.52) | HDAC6ESR2NR1H2BRD4CREBBP | |
| SCHEMBL8558892 | 0.80 | NR1H2 (0.51) | HDAC6ESR2NR1H2BRD4CREBBP | |
| SCHEMBL1174301 | 0.80 | ADORA1 (0.57) | SMN1; SMN2HDAC6ESR2NR1H2BRD4 | |
| SCHEMBL3079148 | 0.79 | HIF1A (0.48) | USP2SMN1; SMN2ESR2BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |