Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 4/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657988 | 0.98 | SLC18A3 (0.53) | SLC18A3HTR2CHTR2BSLC6A4HTR2A | |
| SCHEMBL29501341 | 0.98 | SLC18A3 (0.53) | SLC18A3HTR2CHTR2BSLC6A4HTR2A | |
| Hydrochloric Acid SCHEMBL16835555 | 0.97 | SLC18A3 (0.51) | SLC18A3HTR2CHTR2BSLC6A4HTR2A | |
| Hydrochloric Acid SCHEMBL29877056 | 0.97 | SLC18A3 (0.51) | SLC18A3HTR2CHTR2BSLC6A4HTR2A | |
| Hydrochloric Acid SCHEMBL5271851 | 0.97 | SLC18A3 (0.51) | SLC18A3HTR2CHTR2BSLC6A4HTR2A | |
| SCHEMBL29501431 | 0.92 | SLC18A3 (0.51) | SLC18A3HTR2CHTR2BSLC6A4HTR2A | |
| SCHEMBL22432705 | 0.92 | SLC18A3 (0.51) | SLC18A3HTR2CHTR2BSLC6A4HTR2A | |
| Hydrochloric Acid SCHEMBL22418694 | 0.91 | SLC18A3 (0.50) | SLC18A3HTR2CHTR2BSLC6A4HTR2A | |
| Hydrochloric Acid SCHEMBL30823789 | 0.91 | SLC18A3 (0.50) | SLC18A3HTR2CHTR2BSLC6A4HTR2A | |
| SCHEMBL29501433 | 0.89 | SLC18A3 (0.50) | SLC18A3HTR2CHTR2BSLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |