Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.45 |
| ▸ | F12 | P00748 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KRAS | P01116 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6422033 | 0.90 | CHRM2 (0.51) | HDAC1HDAC6CHRM2CHRM4CHRM1 | |
| SCHEMBL6421557 | 0.89 | HDAC1 (0.52) | HDAC1HDAC6CHRM2CHRM4CHRM1 | |
| SCHEMBL6422069 | 0.87 | HDAC1 (0.51) | HDAC1HDAC6CHRM2CHRM4CHRM1 | |
| SCHEMBL6420928 | 0.87 | HDAC1 (0.51) | HDAC1HDAC6CHRM2CHRM4CHRM1 | |
| SCHEMBL969755 | 0.85 | HDAC6 (0.52) | HDAC1HDAC6CHRM2CHRM4CHRM1 | |
| SCHEMBL968966 | 0.84 | HDAC1 (0.50) | HDAC1HDAC6CHRM2CHRM4CHRM1 | |
| SCHEMBL6421442 | 0.84 | HDAC1 (0.49) | HDAC1HDAC6CHRM2CHRM4CHRM1 | |
| SCHEMBL6423329 | 0.84 | HDAC1 (0.55) | HDAC1HDAC6CHRM2CHRM4CHRM1 | |
| SCHEMBL6423332 | 0.84 | C5AR1 (0.44) | HDAC1HDAC6CHRM2CHRM4CHRM1 | |
| SCHEMBL6783062 | 0.83 | HDAC1 (0.50) | HDAC1HDAC6CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |