Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | KRAS | P01116 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6482888 | 0.93 | HDAC1 (0.55) | HDAC1HDAC6KRASPTGDR2CHRM2 | |
| SCHEMBL6421798 | 0.90 | HDAC1 (0.55) | HDAC1HDAC6KRASPTGDR2CHRM2 | |
| SCHEMBL6421094 | 0.90 | PTGDR2 (0.59) | HDAC1HDAC6KRASPTGDR2CHRM2 | |
| SCHEMBL4185797 | 0.88 | HDAC1 (0.56) | HDAC1HDAC6KRASPTGDR2CHRM2 | |
| SCHEMBL6423858 | 0.88 | HDAC1 (0.53) | HDAC1HDAC6KRASPTGDR2CHRM2 | |
| SCHEMBL6424243 | 0.88 | HDAC1 (0.55) | HDAC1HDAC6KRASPTGDR2CHRM2 | |
| SCHEMBL6421118 | 0.86 | HDAC1 (0.55) | HDAC1HDAC6KRASPTGDR2CHRM2 | |
| SCHEMBL6421345 | 0.85 | HDAC1 (0.67) | HDAC1HDAC6 | |
| SCHEMBL6420742 | 0.84 | HDAC1 (0.54) | HDAC1HDAC6KRASCHRM2CHRM4 | |
| SCHEMBL6422016 | 0.84 | HDAC1 (0.54) | HDAC1HDAC6KRASCHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |