Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896390 | 0.86 | PKM (0.57) | PKMIDO1SMYD3MAPTTDP1 | |
| SCHEMBL4221206 | 0.83 | BRD4 (0.66) | PKMIDO1SMYD3MAPTTDP1 | |
| SCHEMBL2206236 | 0.83 | CA12 (0.53) | PKMIDO1SMYD3MAPTTDP1 | |
| SCHEMBL6424642 | 0.78 | SMYD3 (0.48) | PKMSMYD3KMT2AMAPTTDP1 | |
| SCHEMBL15668360 | 0.77 | PKM (0.58) | PKMSMYD3KMT2AMAPT | |
| SCHEMBL689118 | 0.76 | PKM (0.64) | PKMIDO1SMYD3MAPTTDP1 | |
| SCHEMBL4046212 | 0.76 | GAA (0.57) | SIGMAR1PKMIDO1SMYD3MAPT | |
| SCHEMBL17231389 | 0.76 | PKM (0.64) | PKMIDO1SMYD3KMT2AMAPT | |
| SCHEMBL2203522 | 0.75 | SMYD3 (0.59) | PKMIDO1SMYD3MAPTTDP1 | |
| SCHEMBL6602558 | 0.75 | GAA (0.57) | PKMIDO1SMYD3MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427326-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | SUGEN INC (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-1427326-A2 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | Sugen, Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003015608-A2 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | SUGEN, INC. (US) | 2003-02-27 | — | — | WO | disclosed |