Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 16/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 16/20 | 0.69 |
| ▸ | MMP1 | P03956 | 7/20 | 0.59 |
| ▸ | MMP2 | P08253 | 3/20 | 0.59 |
| ▸ | MMP3 | P08254 | 3/20 | 0.59 |
| ▸ | MMP7 | P09237 | 4/20 | 0.46 |
| ▸ | MMP12 | P39900 | 4/20 | 0.46 |
| ▸ | MMP13 | P45452 | 4/20 | 0.46 |
| ▸ | ACE | P12821 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7858984 | 0.89 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL6422449 | 0.89 | PDE4A (0.87) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL6422745 | 0.86 | PDE4A (0.89) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL6425155 | 0.83 | PDE4A (0.83) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL6822987 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL6422305 | 0.82 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL6423537 | 0.82 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL6423418 | 0.81 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL6423676 | 0.81 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DMMP1 | |
| SCHEMBL6423229 | 0.80 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960096-B1 | SUBSTITUTED BETA-THIOCARBOXYLIC ACIDS | AVENTIS PHARMA INC (US) | 2005-04-06 | — | — | EP | claimed |
| US-6306873-B1 | Substituted β-thiocarboxylic acids | AVENTIS PHARMACEUTICALS PRODUCTS INC. | 2001-10-23 | — | — | US | claimed |
| EP-0960096-A1 | SUBSTITUTED $g(b)-THIOCARBOXYLIC ACIDS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-12-01 | — | — | EP | claimed |
| WO-1998032734-A1 | SUBSTITUTED β-THIOCARBOXYLIC ACIDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-07-30 | — | — | WO | claimed |
| EP-0960096-B1 | SUBSTITUTED BETA-THIOCARBOXYLIC ACIDS | AVENTIS PHARMA INC (US) | 2005-04-06 | — | — | EP | disclosed |
| EP-1486486-A2 | Substituted B-thiocarboxylic acids | Aventis Pharmaceuticals Inc. (US) | 2004-12-15 | — | — | EP | disclosed |
| US-6306873-B1 | Substituted β-thiocarboxylic acids | AVENTIS PHARMACEUTICALS PRODUCTS INC. | 2001-10-23 | — | — | US | disclosed |
| EP-0960096-A1 | SUBSTITUTED $g(b)-THIOCARBOXYLIC ACIDS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998032734-A1 | SUBSTITUTED β-THIOCARBOXYLIC ACIDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-07-30 | — | — | WO | disclosed |