Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 13/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 13/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.58 |
| ▸ | TDP2 | O95551 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3659028 | 0.84 | CYP11B1 (0.79) | CYP11B1CYP11B2CYP1A2TDP2CYP2C9 | |
| SCHEMBL29899622 | 0.84 | CYP11B1 (0.79) | CYP11B1CYP11B2CYP1A2TDP2CYP2C9 | |
| SCHEMBL7648230 | 0.81 | AHR (0.47) | TDP2CRBN | |
| SCHEMBL29849827 | 0.74 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP1A2TDP2CYP2C9 | |
| SCHEMBL29899595 | 0.74 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP1A2TDP2CYP2C9 | |
| SCHEMBL29849907 | 0.74 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP1A2TDP2CYP2C9 | |
| SCHEMBL748904 | 0.74 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP1A2TDP2CYP2C9 | |
| SCHEMBL28610367 | 0.71 | CYP11B1 (0.56) | CYP11B1CYP11B2CYP1A2TDP2CYP2C9 | |
| SCHEMBL7651128 | 0.70 | CRBN (0.47) | TDP2CRBN | |
| SCHEMBL6746651 | 0.70 | CYP11B1 (0.55) | CYP11B1CYP11B2CYP1A2TDP2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427326-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | SUGEN INC (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-1427326-A2 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | Sugen, Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003015608-A2 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | SUGEN, INC. (US) | 2003-02-27 | — | — | WO | disclosed |