Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.41 |
| ▸ | PDE4A | P27815 | 4/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14164953 | 0.91 | PPARG (0.49) | PDE4DPDE4APPARGPPARDPPARA | |
| SCHEMBL14164834 | 0.91 | PPARG (0.49) | PDE4DPDE4APPARGPPARDPPARA | |
| SCHEMBL8890131 | 0.81 | PDE4A (0.43) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL3550785 | 0.78 | PDE4D (0.48) | S1PR1S1PR3PDE4DPDE4APDE4B | |
| SCHEMBL3662407 | 0.77 | TDP2 (0.42) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL15790499 | 0.74 | PDE4D (0.45) | S1PR1S1PR3PDE4DPDE4APDE4B | |
| SCHEMBL16671314 | 0.72 | PDE4A (0.61) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL16956835 | 0.72 | PPARG (0.50) | PDE4DPDE4APDE4BPDE4CPPARG | |
| SCHEMBL4818551 | 0.71 | PPARG (0.51) | PDE4DPDE4APDE4BPDE4CPPARG | |
| SCHEMBL15776890 | 0.71 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605896-A2 | 7-AMINO- ISOINDOLYL COMPOUNDS AMD THEIR PHARMACEUTICAL USES | CELGENE CORPORATION (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004080423-A2 | 7-AMINO- ISOINDOLYL COMPOUNDS AMD THEIR PHARMACEUTICAL USES | CELGENE CORPORATION (US) | 2004-09-23 | — | — | WO | disclosed |