Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.65 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.59 |
| ▸ | PI4KA | P42356 | 2/20 | 0.59 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.59 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.59 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.59 |
| ▸ | DPP4 | P27487 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.59 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.59 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.59 |
| ▸ | GAPDH | P04406 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.59 |
| ▸ | STAT6 | P42226 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14946260 | 1.00 | PRMT5 (0.65) | PRMT5WDR77ADORA3ADORA2API4KA | |
| SCHEMBL3436912 | 1.00 | PRMT5 (0.65) | PRMT5WDR77ADORA3ADORA2API4KA | |
| SCHEMBL14853754 | 1.00 | PRMT5 (0.65) | PRMT5WDR77ADORA3ADORA2API4KA | |
| SCHEMBL2318607 | 1.00 | PRMT5 (0.65) | PRMT5WDR77ADORA3ADORA2API4KA | |
| SCHEMBL29815824 | 1.00 | PRMT5 (0.65) | PRMT5WDR77ADORA3ADORA2API4KA | |
| SCHEMBL13770321 | 0.91 | PRMT5 (0.65) | PRMT5WDR77ADORA3ADORA2API4KA | |
| SCHEMBL14948802 | 0.90 | PRMT5 (0.58) | PRMT5WDR77ADORA3ADORA2API4KA | |
| SCHEMBL12170639 | 0.89 | PI4KA (0.57) | PRMT5WDR77ADORA3ADORA2API4KA | |
| SCHEMBL749583 | 0.88 | PI4KA (0.56) | PRMT5WDR77ADORA3ADORA2API4KA | |
| SCHEMBL749584 | 0.88 | PI4KA (0.56) | PRMT5WDR77ADORA3ADORA2API4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1525209-A2 | 1'-, 2'- AND 3' -MODIFIED NUCLEOSIDE DERIVATIVES FOR TREATING FLAVIVIRIDAE INFECTIONS | Idenix (Cayman) Limited (KY) | 2005-04-27 | — | — | EP | disclosed |
| WO-2004003000-A2 | 1’-, 2'- AND 3'- MODIFIED NUCLEOSIDE DERIVATIVES FOR TREATING FLAVIVIRIDAE INFECTIONS | IDENIX (CAYMAN) LIMITED (KY) | 2004-01-08 | — | — | WO | disclosed |