Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCK1 | P35558 | 16/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978661 | 0.89 | PCK1 (0.53) | PCK1HTTNR3C1 | |
| SCHEMBL3982176 | 0.86 | PCK1 (0.50) | PCK1HTTNR3C1 | |
| SCHEMBL3977690 | 0.86 | PCK1 (0.52) | PCK1HTTNR3C1 | |
| SCHEMBL4613199 | 0.83 | PCK1 (0.47) | PCK1ALDH1A1 | |
| SCHEMBL3981170 | 0.82 | PCK1 (0.56) | PCK1 | |
| SCHEMBL3980272 | 0.81 | PCK1 (0.41) | PCK1KDM4EALDH1A1TP53TSHR | |
| SCHEMBL3981417 | 0.81 | PCK1 (0.43) | PCK1ALDH1A1HTTNR3C1 | |
| SCHEMBL4615524 | 0.81 | PCK1 (0.48) | PCK1 | |
| SCHEMBL3977836 | 0.80 | PCK1 (0.41) | PCK1ALDH1A1HTT | |
| SCHEMBL3987448 | 0.80 | PCK1 (0.43) | PCK1ALDH1A1HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515972-A1 | AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003106459-A1 | AMIDE SUBSTITUTED XANTHINE DERIVATIVES WITH GLUCONEOGENESIS MODULATING ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2003-12-24 | — | — | WO | disclosed |