PCK1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3978767	1.00	20/20
SCHEMBL3981163	1.00	20/20
SCHEMBL4092479	1.00	20/20
SCHEMBL4614239	1.00	20/20
SCHEMBL4614417	1.00	20/20
SCHEMBL3981765	0.95	20/20
SCHEMBL3978655	0.94	20/20
SCHEMBL3983384	0.88	20/20
Trifluoroacetic Acid (SCHEMBL4614421)	0.88	20/20
SCHEMBL3983096	0.87	20/20
SCHEMBL3976935	0.86	20/20
SCHEMBL4613197	0.86	20/20
SCHEMBL3977016	0.83	20/20
SCHEMBL3984441	0.82	20/20
SCHEMBL4612904	0.82	20/20
SCHEMBL4615388	0.81	20/20
SCHEMBL3978817	0.81	20/20
SCHEMBL3980864	0.81	20/20
SCHEMBL4614781	0.81	20/20
SCHEMBL6443781	0.81	20/20

Clinical trials — most relevant to PCK1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of a Basal/Pre-Meal Insulin Strategy (Detemir/Aspart) on Insulin Secretion and Action in Type 2 Diabetes	PHASE4	COMPLETED
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity	PHASE4	COMPLETED
Pioglitazone Study of Triglyceride Changes in Subjects With Type 2 Diabetes After Conversion From Rosiglitazone.	PHASE4	COMPLETED
Topical Metformin Emulgel VS Salicylic Acid Peeling in Treatment of Acne Vulgaris	PHASE4	UNKNOWN
Chronic Versus Acute Dosing of Sodium Citrate for Swimming 200m	PHASE3	COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Bempedoic Acid Therapy for Polycystic Kidney Disease	PHASE2	NOT_YET_RECRUITING
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI)	PHASE2	RECRUITING
The Effect of Glucagon on Rates of Hepatic Mitochondrial Oxidation in Man Assessed by PINTA	PHASE1	COMPLETED
Effect of Acute Fructose Load in Human	nan	COMPLETED
Dried Fruit and Postprandial Glycemia Trial	nan	UNKNOWN
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
The Role of Sugars in Fat Accumulation in the Liver	nan	RECRUITING
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Bempedoic Acid in PPCI Impact on Clinical Outcome and Inflammatory Markers	nan	NOT_YET_RECRUITING
Role of the Liver in Glucose Homeostasis Using Metabolic Imaging	nan	COMPLETED
Alternative Substrates in the Critically Ill Subject	nan	COMPLETED
Effect of Age on Glucose and Lipid Metabolism	nan	COMPLETED
Novel Inhibitors of Lipolysis in the Treatment of Lipid a Glucose Metabolism in Obstructive Sleep Apnea Syndrome	nan	UNKNOWN
Effects of Dual-Source Carbohydrate Intake and Liver Glycogen Repletion After Overnight Fasting.	nan	NOT_YET_RECRUITING
Insulin Resistance in Relation to Hyperthyroidism and Hypothyroidism	nan	UNKNOWN
Clinical Study to Evaluate Safety and Efficacy of Amino Acid in Healthy Individuals	nan	COMPLETED
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
The Study of HIV Protease Inhibitors and Their Effects on Glucose Metabolism	nan	COMPLETED
Fluorodeoxyglucose Positron Emission Tomography (FDG PET) Findings in Patients With Phenylketonuria Before and After KUVAN Therapy	nan	COMPLETED
METabolic PROFILE of Hepatocarcinoma and Pancreatic Tumors	nan	RECRUITING
Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection.	nan	COMPLETED
Acute Effect of Fructose on Lipid Metabolism and Gender Differences	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PCK1 binder may also engage these)

Protein	Name	Similarity
Q5R5J1	—	1.000	Q5R5J1 →
P07379	—	1.000	P07379 →
Q9Z2V4	—	1.000	Q9Z2V4 →
Q8HYZ4	—	0.999	Q8HYZ4 →
P05153	—	0.998	P05153 →
Q5L4X1	—	0.998	Q5L4X1 →
O83159	—	0.998	O83159 →
Q8KAD1	—	0.997	Q8KAD1 →
A0A4X1UM84	—	0.997	A0A4X1UM84 →
Q256B8	—	0.997	Q256B8 →
Q73TS2	—	0.996	Q73TS2 →
Q08262	—	0.996	Q08262 →
Q821M4	—	0.996	Q821M4 →
PCK2	Phosphoenolpyruvate carboxykinase [GTP], mitochondrial	0.996	landscape →
P20007	—	0.996	P20007 →
Q9Z755	—	0.996	Q9Z755 →
Q82I71	—	0.996	Q82I71 →
Q0RCJ7	—	0.996	Q0RCJ7 →
A3DJE3	—	0.996	A3DJE3 →
Q9PLL6	—	0.995	Q9PLL6 →
Q5P2P8	—	0.995	Q5P2P8 →
A1U995	—	0.995	A1U995 →
Q2J645	—	0.995	Q2J645 →
P58306	—	0.994	P58306 →
Q746Y3	—	0.994	Q746Y3 →
Q8FM16	—	0.994	Q8FM16 →
Q2IFT1	—	0.994	Q2IFT1 →
Q9HLV2	—	0.994	Q9HLV2 →
Q4JY04	—	0.994	Q4JY04 →
Q75JD5	—	0.994	Q75JD5 →