Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.77 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.69 |
| ▸ | RORC | P51449 | 2/20 | 0.63 |
| ▸ | RORA | P35398 | 1/20 | 0.63 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.63 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.63 |
| ▸ | RORB | Q92753 | 1/20 | 0.63 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.61 |
| ▸ | ALPL | P05186 | 1/20 | 0.59 |
| ▸ | ALPI | P09923 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | ALPG | P10696 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5604160 | 0.89 | ESR1 (0.73) | ESR1TSHRMAPK1KMT2AHSD17B10 | |
| SCHEMBL28133849 | 0.89 | CNR1 (0.69) | ESR1TSHRMAPK1KMT2AHSD17B10 | |
| SCHEMBL6302204 | 0.88 | ESR1 (0.88) | ESR1TSHRMAPK1KMT2AHSD17B10 | |
| SCHEMBL11404947 | 0.88 | ESR1 (0.67) | ESR1TSHRMAPK1KMT2AHSD17B10 | |
| SCHEMBL2603075 | 0.88 | ESR1 (0.71) | ESR1TSHRMAPK1KMT2AHSD17B10 | |
| SCHEMBL10904389 | 0.88 | ESR1 (1.00) | ESR1TSHRMAPK1KMT2AHSD17B10 | |
| SCHEMBL28728523 | 0.85 | CNR1 (0.70) | ESR1TSHRMAPK1KMT2AHSD17B10 | |
| SCHEMBL10438567 | 0.85 | ESR1 (0.79) | ESR1TSHRMAPK1KMT2AHSD17B10 | |
| SCHEMBL6297282 | 0.84 | ESR1 (0.70) | ESR1TSHRMAPK1KMT2AHSD17B10 | |
| SCHEMBL5467499 | 0.84 | ESR1 (0.58) | ESR1TSHRMAPK1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10439252-B2 | Electrolyte solution for electrochemical device, and electrochemical device | FUJIFILM WAKO PURE CHEMICAL CORPORATION (JP) | 2019-10-08 | — | — | US | disclosed |
| US-10022376-B2 | Pyrazolopyridines and pyrazolopyrimidines | PFIZER INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-20170071946-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER INC. (US) | 2017-03-16 | — | — | US | disclosed |
| US-9518052-B2 | Pyrazolopyridines and pyrazolopyrimidines | PFIZER INC. (US) | 2016-12-13 | — | — | US | disclosed |
| US-20150364792-A1 | ELECTROLYTE SOLUTION FOR ELECTROCHEMICAL DEVICE, AND ELECTROCHEMICAL DEVICE | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2015-12-17 | — | — | US | disclosed |
| US-20150329542-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER INC. | 2015-11-19 | — | — | US | disclosed |
| US-6967196-B1 | Sulfonamide compounds and uses thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| US-6818367-B2 | A BENZOXAZOLE | EASTMAN KODAK COMPANY | 2004-11-16 | — | — | US | disclosed |
| US-20040209180-A1 | SUPPORT WITH REDUCED OPTICAL BRIGHTENER MIGRATION | BANK OF AMERICA, N.A., AS AGENT | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10022376-B2 | Pyrazolopyridines and pyrazolopyrimidines | CBR3, HRH4, REN | ESR1 2887/4885TSHR 330/4885MAPK1 2646/4885 |
| US-20150329542-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | HRH2, HRH4, HRH1 | ESR1 3247/4885TSHR 85/4885MAPK1 3196/4885 |
| US-20170071946-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | HRH2, HRH4, HRH1 | ESR1 3247/4885TSHR 85/4885MAPK1 3196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.